1 microRNA - mediated transformation by the Kaposi ’ s Sarcoma - associated
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Classic Kaposi sarcoma presenting as elephantiasis nostras verrucosa
Kaposi sarcoma is a malignant disease that originates fromthe lymphatic system. Different epidemiological, clinical andhistopathological variants of this neoplasm have been identified.Classic Kaposi sarcoma is one of the four main clinico-epidemiologicvariants. Cutaneous lesions vary from pink patches to darkviolet plaques, nodules or polyps, depending on clinical variantand stage. Kaposi sarco...
متن کاملسودوکاپوسی سارکوما در اسکار
Pseudo-Kaposi sarcoma (PKS) or acroangiodermatitis is a benign angioproliferative disease which shares many clinical and histopathological features with Kaposi sarcoma. Clinical presentations include violaceous macules, papules or plaques in the lower extrimities, which is usually associated with chronic venous insufficiency or congenital or acquired arterio-venous malformations. Its pathogenes...
متن کاملSequence analysis of Kaposi sarcoma-associated herpesvirus (KSHV) microRNAs in patients with multicentric Castleman disease and KSHV-associated inflammatory cytokine syndrome.
BACKGROUND Kaposi sarcoma-associated herpesvirus (KSHV) encodes 12 pre-microRNAs that yield 25 mature microRNAs. We previously reported phylogenetic analysis of the microRNA-coding region of KSHV from Kaposi sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman disease (MCD) patients. We observed a high level of conservation for most sequences but also a divergent cluster of...
متن کاملA microRNA Encoded by Kaposi Sarcoma-Associated Herpesvirus Promotes B-Cell Expansion In Vivo
The human gammaherpesvirus Kaposi sarcoma-associated herpesvirus is strongly linked to neoplasms of endothelial and B-cell origin. The majority of tumor cells in these malignancies are latently infected, and latency genes are consequently thought to play a critical role in virus-induced tumorigenesis. One such factor is kshv-miR-K12-11, a viral microRNA that is constitutively expressed in cell ...
متن کاملFrequency of malignant skin tumors in renal transplant recipients in Imam Reza hospital of Mashhad, Iran
Background: The higher frequency of malignant skin tumors is of great significance in renal transplant recipients (RTRs) who should receive immunosuppressive therapy for a long time. This study was designed to determine the frequency of malignant skin tumors in RTRs in Imam Reza Hospital, Mashhad, Iran, in 2001-2002.Method: This descriptive study was performed on 322 recipients who were examine...
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تاریخ انتشار 2014